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KMID : 0545120150250111966
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Journal of Microbiology and Biotechnology
2015 Volume.25 No. 11 p.1966 ~ p.1969
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A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis
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Kim Hye-Jin
Rather Irfan A.
Kim Hyun-Wook
Kim Sung-Soo
Kim Tae-Eun
Jang Jae-Young
Seo Ji-Min
Lim Jeong-Heui
Park Yong-Ha
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Abstract
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Canine atopic dermatitis (CAD) is a ubiquitous, chronic inflammatory skin disorder prevalent in dogs, which results in production of abnormal levels of IgE antibodies in reciprocation to an allergen challenge. In this study, administration of the probiotic strain Lactobacillus sakei probio-65 for 2 months significantly reduced the disease severity index in experimental dogs diagnosed with CAD. In addition, one month pre-medication of L. sakei probio-65 revealed significant difference in the PVAS score in experimental dogs for both probio-65 and placebo groups. However, post 2 months treatment resulted in a significant decrease in the CASESI score values in the probio-65-treated group (p < .0.06).
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KEYWORD
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Canine atopic dermatitis, Lactobacillus sakei, probiotics, skin disorder
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